Volume 11, Number 1, 2, 3 & 4, January - December, 2023 |
Abubakar SB, Mamman AI, Abdul MA, Yunusa A |
Hormonal contraceptives have been associated with alteration in haemostatic profile resulting in increased risk of thromboembolic disorders. The objective of the study was to determine the effect of duration of hormonal contraceptives use on haemostatic parameters. This is a cross sectional study involving 140 consenting subjects who were on hormonal contraceptives for different period ranging from 6 to 42 months. A structured questionnaire was administered to obtain information required. Venous blood samples were collected into appropriate containers for FBC and assay of haemostatic parameters (PT, APTT and TT) using standard methods. The results were analyzed using the statistical package for social sciences (SPSS) version 17.0 software. Statistical significance was based on p value < 0.05. The subjects were classified based on the duration of contraceptive used into six monthly intervals and the mean tests result for each group obtained. There was progressive shortening of the PT and APTT from 12.30±1.33 and 29.97±5.03 seconds at 7-12 months to 10.93±1.31 and 26.60± 5.02 at 37- 42 months respectively. The TT also shortened from18.26±2.59 at 7-12 months and 16.05±1.64 at 37-42 months. The platelets count shows a gradual raise from 252.94±10.36 at 7-12 to 316.17±31.94 at 37- 42 months. The use of hormonal contraceptives affects the haemostatic parameters resulting in increase thrombogenic risk which worsens with duration of use. We therefore recommend that before commencement of hormonal contraceptives, women should have a base line coagulation screening test and if feasible, monitored at six monthly intervals. |
10.47837/cmj.19770126.nma.20142410121 |
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