Call for Paper
Submission is open for Volume 10 Number 3 - 4 July - December 2022 Click here to submit paper
Indexing
Chairman NMA
Dr Umar Muhammad Muktar
Chairman NMA Sokoto
Abstract
| Volume 10 Number 3 - 4 July - December 2022 |
| Abubakar, MG, Abdulsalam, RM, Yusuf, T2, Umar, ZU |
| Background: Currently, the prevention and treatment of peptic ulcer diseases are among global health concerns. Nigella sativa seed oil is a rich source of flavonoids, alkaloids, tannins, phenols, and minerals with similar principles against gastric ulcers. Aim and objective: The present study is to evaluate the protective effects of Nigella sativa seed oil and zinc gluconate on ethanol-induced gastric mucosal damage in Wistar rats. Methodology: Fifty (50) male Wistar rats were randomly divided into five groups of 5 rats each (25) for gastric mucosal damage and (25) for secretion studies. Group I is the control that received distilled water, Group II received 1 ml of absolute ethanol, while groups III, IV, and V were treated by orogastric gavage with 5 ml/kg of Nigella sativa oil, 50 mg/kg of zinc gluconate, and 5ml/kg of Nigella sativa oil plus 50mg/kg of zinc gluconate respectively. The rats were pre-treated for 7 days before induction of gastric ulcer. After forty-eight hours of fast and the last administration of zinc and Nigella sativa seed oil, ulcer was induced and animals were later sacrificed using standard procedures to quantitatively assessed the protective effects of Nigella sativa seed oil and zinc gluconate on gastric mucosal damage. Results: Pretreatment with Nigella sativa seed oil reduced gastric acid titer and mucosal damage with raised preventive index. Nigella sativa seed oil and the zinc gluconate treated groups have elicited a gastroprotective effect. Conclusion: This study showed the gastro-protective effects of Nigella sativa seed oil and zinc gluconate on ethanol-induced gastric mucosal damage in Wistar rats. Keywords: Peptic ulcer diseases; Nigella sativa seed oil; gastric acid titer; preventive index |
| 10.47837/CMJ.202192.6 |
| Download |